Natalie Morales was born in Miami, Florida, and is of Cuban descent. She studied Theatre at Miami Dade College and Florida International University. In 2006, Natalie landed a guest star role on an episode of the CBS drama, CSI: Miami (2002): CSI: Miami: Darkroom (2006). In 2008, Natalie starred on the ABC Family series, The Middleman (2008). While the series, itself, lasted only one season, it has developed a cult following.

Natalie has since gone on to act, write and direct various projects. She was a series regular on the first season of White Collar (2009) and was then cast in films, such as Wall Street: Money Never Sleeps (2010) and Going the Distance (2010) in 2010. She has recurred on Parks and Recreation (2009), Girls (2012), & Santa Clarita Diet (2017). She has directed and acted in separate episodes of Room 104 (2017), and stars on the NBC sitcom, Abby’s (2019).