Stanley Kamel was born in New Brunswick, New Jersey on January 1, 1943 and was raised in South River, New Jersey. He attended high school at Rutgers Prepatory School (graduated 1961) in Somerset, New Jersey and received his college degree from the Boston University School of Fine Arts in 1965. Kamel got his start in acting with bit parts off-Broadway before his big break into television (as a regular cast member) portraying Eric Peters #2 on Days of Our Lives (1965) from 1972 to 1976.

He played a lot of different characters over the years, and his face was well known to most. He had a recurring role as the unscrupulous psychiatrist, Dr. Graham Lester on Murder One (1995). He also had recurring roles on the hits Melrose Place (1992) and Beverly Hills, 90210 (1990). Late in his career, Kamel was probably best known for playing Dr. Charles Kroger on Monk (2002) starring Tony Shalhoub.

On April 8, 2008, Kamel was found dead in his Hollywood Hills (Los Angeles) home by his long time agents, Donna Massetti and Marilyn Szatmary, having died of a heart attack. Kamel was only 65 years old.