Anthony Perkins was born April 4, 1932 in New York City to Janet Esselstyn (Rane) and Osgood Perkins, an actor of both stage and film. His paternal great-grandfather was noted engraver Andrew Varick Stout Anthony.

Perkins attended the Brooks School, the Browne & Nichols School, Columbia University and Rollins College. He made his screen debut in The Actress (1953), and was nominated for a Best Supporting Actor Oscar Friendly Persuasion (1956). Four years later, he appeared in what would be his most memorable role to date, Norman Bates in Psycho (1960).